Our goal is to understand the molecular mechanisms of chromosome segregation.
Aneuploidy is one of the hallmarks in cancer cells. It is known to promote the development of cancer. A major cause of aneuploidy is derived from chromosome mis segregation in mitosis. Therefore, a better understanding of the mechanisms of proper chromosome segregation will help decipher the underlying causes of cancer and provide theoretical bases for clinical applications.
ORCID Identifier: 0000-0001-5038-3327
MyNCBI Link: https://www.ncbi.nlm.nih.gov/myncbi/hong.liu.5/bibliography/public/
Selected Publications:
1. Liu,H, Qu, Q., Warrington R.,Rice, A., Cheng N., and Yu, H., (2015) Mitotic Transcription Installs Sgo1 at centromeres to Coordinate Chromosome Segregation. Molecular Cell,59(3), 426-436.
2. Palozola KC, Donahue G, LiuH, Grant GR, Becker JS, Cote A, Yu H, Raj A, Zaret KS. (2017) . Mitotic transcription and waves of gene reactivation during mitotic exit. Science, 2017 Oct6;358(6359):119-122
3. Qu Q, Zhang Q, Yang L,Chen Y, Liu H(2019) SET binding to Sgo1 inhibitsSgo1-cohesin interactions and promotes chromosome segregation. J Cell Biol. 2019 Aug 5;218(8):2514-2528.
4. Yujue Chen, Qian Zhang, Zhen Teng, and HongLiu*.(2021) Centromeric Transcription Maintain CentromericCohesion in Human Cells. J Cell Biol. 2021 (DOI:10.1083/jcb.202008146)
Key Words: Aneuploidy; Chromosome instability; Chromosome segregation; Mitosis; Centromere
Lab website:
https://medicine.tulane.edu/liu-laboratory
