The Molecular Histopathology and Analytical Microscopy Core (MHAM) is a state-of-the-art facility created to provide advanced histopathology and microscopy services to investigators and clinicians conducting research at LSU LCMC Health Cancer Center, including promising junior investigators of the Center for Translational Viral Oncology (CTVO). The MHAM provides researchers with access to archival clinical samples, experimental planning design, and imaging studies on the histology and pathology of tissues, the expression of cell surface, and intracellular molecules including viral proteins, using bright field and confocal microscopy, immunohistochemistry, immunohistofluorescence, multiplexing, in situ hybridization, and in situ proximity ligation (DuoLink). These multiple methods are used to determine protein expression patterns and localization, mRNA levels, their subcellular localization, and protein-protein and RNA-protein interactions in the cells and tissues. Moreover, the MHAM Core assists investigators in developing the necessary imaging and data for the submission of manuscripts and grants.
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