Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, Louisiana Cancer Research Center, New Orleans, LA, USA
Description of lab/research: The Drosophila model For Cancer Research
We use the Drosophila intestine model to investigate how intestinal stem cells are regenerated in response to physiological challenges, and our studies found that infection of pathogenic bacteria can drive the committed cells (eneteroblasts) to generate stem cells through EGFR-Ras signaling. In addition, we use the Drosophila follicle epithelium model to study how the invasive directions of polarity-deficient cells are regulated.
ORCID identifier: https://orcid.org/0000-0001-5011-6034
MyNCBI Link: https://www.ncbi.nlm.nih.gov/myncbi/aiguo.tian.1/bibliography/public/
Lab website: https://medicine.tulane.edu/departments/biochemistry-molecular-biology-tulane-center-aging/faculty/aiguo-tian-phd
Selected Publications:
1. Tian A*, Morejon V, Kohoutek S, Huang YC, Deng WM, Jiang J. Damage-induced regeneration of the intestinal stem cell pool through enteroblast mitosis in the Drosophila midgut. The EMBO J. 2022 Oct 4;41(19):e110834. PubMed Central PMCID: PMC9531297. * Corresponding author
2. Gong SY, Zhang YC, Tian AG, Deng WM. Tumor models in various Drosophila tissues. Wires Mech Dis. 2021;13(6). doi: ARTN e1525 10.1002/wsbm.1525. PubMed PMID:WOS:000708934000002.
