Research in my laboratory in the past fifteen years has focused on three main areas: 1) therapeutic development for treatment of breast cancer, 2) drug metabolism and disposition, and 3) proteomic studies on mechanisms of drug action and for discovery of novel therapeutic targets in cancer. As demonstrated in my peer reviewed publications and current and past grant support, our laboratory has acquired a broad range of research expertise from design and synthesis of active compounds, analysis of their metabolism, in vitro and in vivo experiments testing their biological activities, to proteomic characterization of cellular alterations in response to drug action. As a result, several lead oncology drug candidates from our laboratory have been advanced to late stages of preclinical studies through technology transfer and licensing. Our laboratory is experienced in tumor xenografting and treatment with experimental anticancer agents and well prepared for the proposed research.
