Dr. Wu’s laboratory has been using a wide range of in vitro and in vivo model systems to characterize the roles of epigenetics, epitranscriptomics, microRNAs, long non-coding RNAs, eicosanoids, and other key signaling molecules (including TGF-β, EGFR, hedgehog, notch, Hippo/YAP and Wnt/β-catenin signaling pathways, among others) in hepatobiliary cancers including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). We strive to identify new mechanisms of hepatobiliary carcinogenesis and to provide new implication for the treatment of hepatobiliary cancers.
Education M.D., Ph.D.
Selected Publications
Ma W, Han C, Zhang J, Song K, Chen W, Kwon H, and Wu T. The Histone Methyltransferase G9a Promotes Cholangiocarcinogenesis through Regulation of the Hippo Pathway Kinase LATS2 and YAP Signaling Pathway. Hepatology. 2020 Oct;72(4):1283-1297.
Song K, Kwon H, Han C, Chen W, Zhang J, Ma W, Dash S, Gandhi CR, and Wu T. Yes-associated protein in Kupffer cells enhances the production of cytokines and promotes the development of non-alcoholic steatohepatitis. Hepatology. 2020 Jul;72(1):72-87.
Zhang J, Han C, Ungerleider N, Chen W, Song K, Wang Y, Kwon H, Ma W, and Wu T. A transforming growth factor-β and H19signaling axis in tumor-initiating hepatocytes that regulates hepaticcarcinogenesis. Hepatology 2019 Apr;69(4):1549-1563.
Kwon H, Song K, Han C, Chen W, Wang Y, Dash S, Lim K, and Wu T. Inhibition of hedgehog signaling ameliorateshepatic inflammation in mice with nonalcoholic fatty liver disease. Hepatology.2016 Apr;63(4):1155-69.
Yao L, Han C, Song K, Zhang J, Lim K, and Wu T. Omega-3 polyunsaturated fatty acidsupregulate 15-PGDH expression in cholangiocarcinoma cells by inhibitingmiR-26a/b expression. Cancer Res.2015, 75(7):1388-98.
Song K, Han C, Zhang J, Lu D, Dash S, Feitelson M, Lim K, and WuT. Epigenetic regulation of miR-122 byPPARγ and hepatitis B virus X protein in hepatocellular carcinoma cells. Hepatology. 2013, 58(5):1681-1692.
Wang Y, Han C, Lu L, Magliato S and Wu T. Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells. Hepatology.2013, 58(3):995-1010.
Zhang J, Han C and Wu T. MicroRNA-26a promotes cholangiocarcinoma growth by activating beta-catenin. Gastroenterology.2012, 143:246–256.
Lu D, Han C and Wu T. Microsomal prostaglandin E synthease-1 (mPGES-1) promotes experimental cholangiocarcinogenesis and tumor progression through inhibition of PTEN pathway. Gastroenterology. 2011, 40(7):2084-94.
Keywords Hepatobiliary cancer, liver cancer, liver pathology, hepatocellular carcinoma, cholangiocarcinoma,
