I am a cancer biologist interested in mechanistic studies of cancer metastases and development of targeted protein degradation (TPD) techniques. My current research mainly focuses on deciphering the underlying mechanisms of tumor dormancy, progression, and drug resistance in prostate cancer bone metastases and developing novel agents to target vital players discovered in these biological processes. I am now supported by three DOD grants (two as PI, another as Co-I) to develop novel TPD-based technology to decipher locus-specific transcription regulatory proteome and design a universal pipeline to develop PROTAC degraders against hard-to-drug target proteins in prostate cancer (PCa).
