Mylab is interested in immunology and inflammation with a particular interest inCD4+ T cells including regulatory T cells and Th17 cells that have beenimplicated in cancer. My lab hasextensively used RNAseq and single cell sequencing to study T –cells duringinflammation and how they signal to neighboring tissues. We established the CTRII NGS core in 2017 ( https://medicine.tulane.edu/centers-institutes/tulane-center-translational-research-infection-inflammation) which supports single cell chemistriesacross the Tulane Campus. We also havean interest in immunotherapy using cytokines or CAR-T cells. I can contribute my expertise in immunologyas well as expertise in single cell genomics. My lab has partnered with other labs on head and neck cancer, lungcancer as well as mesothelioma. I havealso been MPI on a P30 grant as lead of a NGS core.
Education:
ORCID identifier: 0000-0001-5151-6304
https://www.ncbi.nlm.nih.gov/myncbi/jay.kolls.1/bibliography/public/
Selected Publications:
W Ouyang, JKKolls, Y Zheng The biological functions of T helper 17 cell effector cytokinesin inflammation. Immunity 28 (4), 454-467 2137,2008
P Ye, FHRodriguez, S Kanaly, KL Stocking, J Schurr, P Schwarzenberger, et. al.
Requirement ofinterleukin 17 receptor signaling for lung CXC chemokine and granulocytecolony-stimulating factor expression, neutrophil recruitment, and host defense.The Journal of Experimental Eedicine 194 (4), 519-528, 2001
SJ Aujla, YRChan, M Zheng, M Fei, DJ Askew, DA Pociask, TA Reinhart, et. al. IL-22 mediatesmucosal host defense against Gram-negative bacterial pneumonia
Nature medicine14 (3), 275-281, 2008
A Cossarizza, HDChang, A Radbruch, A Acs, D Adam, S Adam‐Klages, et. al. Guidelinesfor the use of flow cytometry and cell sorting in immunological studies. Europeanjournal of immunology 49 (10), 1457-1973 1405 2019
P Miossec, JKKolls Targeting IL-17 and TH17 cells in chronic inflammation
Nature reviewsDrug discovery 11 (10), 763-776
Iwanaga N, ChenK, Yang H, Lu S, Hoffmann JP, Wanek A, McCombs JE, Song K, Rangel-Moreno J,Norton EB, Kolls JK. Vaccine-driven lung TRM cells provide immunity againstKlebsiella via fibroblast IL-17R signaling. Sci Immunol. 2021 Sep 10;6(63).
Keywords/Tags: Th17 cells, single cell RNAseq, T cell immunology, gene therapy
