Wilms tumor (WT) is an embryo tumor and believed to arise from immature kidney cells, nephron progenitor cells (NPCs), which have failed to differentiate properly. Genome-wide studies showed the close link between NPCs of the developing human kidney and WT oncogenesis. We are studying the novel molecular mechanisms of epigenetic modulators in the tumorigenesis of WT, and will provide new approaches for the treatment of WT.
ORCID identifier: 0000-0002-3411-4597
MyNCBI Link: https://www.ncbi.nlm.nih.gov/myncbi/1dEV5uRMdcdAm/bibliography/public/
Selected Publications:
a. Liu H*, Ngo NYN, Herzberger KF, Gummaraju M, Hilliard S, Chen CH. (*Corresponding Author) Histone deacetylases 1 and 2target gene regulatory networks of nephron progenitors to control nephrogenesis. Biochem Pharmacol. 2022Dec; 206:115341. doi: 10.1016/j.bcp.2022.115341. Epub 2022 Nov7. PubMed PMID: 36356658.
b. Chen C, Ngo NYN, Wang A, El-Dahr S, LiuH. Overactivation of histone deacetylases and EZH2 in Wilms tumorigenesis. Genes &Diseases. Accepted. https://doi.org/10.1016/j.gendis.2022.10.026
c. Liu H, Hilliard S, Kelly E, Chen CH, Saifudeen Z, El-Dahr SS. The polycomb proteins EZH1 and EZH2 co-regulate chromatin accessibility and nephron progenitor cell lifespan in mice. J Biol Chem. 2020Aug 14;295(33):11542-11558. PMCID: PMC7450110.
d. Liu H*, Chen S, Yao X, Li Y, Chen CH, Liu J, Saifudeen Z, El-Dahr SS. (*Corresponding Author) Histone deacetylases 1 and 2 regulate the transcriptional programs of nephron progenitors and renal vesicles. Development. 2018 May 18;145(10):dev153619. PMCID:PMC6001373.
e. Zhou X, Hao Q, Liao P, Luo S, Zhang M, Hu G, LiuH, Zhang Y, Cao B, Baddoo M, Flemington EK, Zeng SX, Lu H. Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator. Elife. 2016 Jun 10;5:e15099. PMCID: PMC4943851.
f. Chao T, Zhou X, Cao B, Liao P, Liu H,Chen Y, Park HW, Zeng SX, Lu H. Pleckstrin homology domain-containing proteinPHLDB3 supports cancer growth via a negative feedback loop involving p53. Nat Commun. 2016 Dec 23;7:13755. PMCID: PMC5196188.
Keywords/Tags: Histone deacetylase, EZH2, Kidney, Wilms Tumor
Link to website: https://medicine.tulane.edu/departments/pediatrics-tulane-cancer-center/faculty/hongbing-liu-phd
