Smart therapeutics for cancer control and for limiting normal tissue toxicity of cancer therapies.
A majority of patients that undergo radiation for head and neck cancer and a substantial number of patients that undergo total-body irradiation (TBI) prior to bone marrow transplantation suffer from off-target effects of head and neck radiation such as salivary gland hypofunction and oral mucositis. A pressing issue in cancer therapy is the mitigation of off-target toxicity that impairs the patient’s quality of life, nutritional status, and the compliance to cancer treatments. Normal tissue toxicity limits the use of high-dose cancer therapy and is invariably responsible for cancer treatment interruptions. Engineering target selectivity is the focus of the lab in redesigning radioprotective therapies. Smartness in gene therapy, direct protein transfer, and small molecule therapies can limit radiation effects on normal tissues while sensitizing cancer cells - thus achieving the benefit of improved cancer control without undue morbidity.
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28. Timiri Shanmugam PS, Nair RP, De Benedetti A, CalditoG, Abreo F, Sunavala-Dossabhoy G. Tousled kinase activator, gallic acid, promotes homologous recombinational repair and suppresses radiation cytotoxicity in salivary gland cells. Free Radical Biology Medicine. 2016; 93:217-26. doi: 10.1016/j.freeradbiomed.2015.12.029. E pub 2016 Feb 15.
29. Timiri Shanmugam PS, Nair RP, De Benedetti A, Caldito G, Abreo F, Sunavala-Dossabhoy G.DNA damage response and repair data with pharmacological modulators of Tousled.Data Brief. 2016; 7: 1073–1077. doi: 10.1016/j.dib.2016.03.075
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36. Nair RP, Timiri Shanmugam PS, Sunavala-Dossabhoy G. Discretionary transduction of MMP-sensitized Tousled in head and neck cancer. Molecular Therapeutics - Oncolytics. 2019; 14:57-65. doi:10.1016/j.omto.2019.02.003.
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38. Sunavala-Dossabhoy G, Spielman AI. Restructuring dental education in a post-COVID-19 era. Oral Diseases. 2022 Apr; 28Suppl 1:920-921. doi: 10.1111/odi.13580.
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41. Sunavala-Dossabhoy G. Disorder at the start: The contribution of dysregulated translation initiation to cancer therapy resistance. Frontiers in Oral Health Dec; 2:765931. doi: 10.3389/froh.2021.765931.
42. Coletta R, Sunavala-Dossabhoy G. Orofacial clefts: A compendium on non-syndromic cleft lip and cleft palate. Oral Diseases 2022Jul; 28(5):1301-1304. doi: 10.1111/odi.14238.
43. Xu W, Sunavala-Dossabhoy G, Spielman AI. Chemo sensory loss in COVID-19. Oral Diseases 2022 Nov; 28 Suppl 2:2337-2346.doi: 10.1111/odi.14300.
44. Umarji HR, Parikh N, Deniz S, Sunavala-Dossabhoy G. Dr. Ani John (1950-2007): An exemplary dental educator and administrator andthe first female President of the Indian Academy of Oral Medicine andRadiology. Oral Diseases. 2023 Mar;29 Suppl 1:893-897. doi: 10.1111/odi.14519.
45. Sunavala-Dossabhoy G, Petti S. Effect of recombinant human thyroid stimulating hormone on long-term salivary gland dysfunction in thyroid cancer patients treated with radioactive iodine. A systematic review. Oral Oncology. 2023 Jan; 136:106280. doi:10.1016/j.oraloncology.2022.106280. Epub 2022 Dec 14.
46. Sunavala-Dossabhoy G, Buduneli N. Women pioneers in dental sciences. Oral Diseases. 2023 Mar;29 Suppl 1:857-859. doi:10.1111/odi.14534.
47. Lodi G, Sunavala-Dossabhoy G, Petti S. In defence of open scientific discussion. Reply to McMahon Article. Oral Diseases. 2023May; 29: 1887-1888. doi: 10.1111/odi.14560.
ORCID:0000-0001-9204-6513
