The Payton-Stewart research projects involves the design, synthesis, characterization, and biological screening of novel anti-canceragents.
Dr. Payton-Stewart's research involvesunderstanding the molecular mechanism and biological activity of naturally occurring plant phytoalexins and their analogs as they pertain to breast carcinomas. One major focus of the Payton-Stewart research laboratory is to identify the structural activity relationship(SAR) of synthesize analogs. This research laboratory designs anti-cancer agents for various forms of cancer such prostate, triple negative breast cancer, endocrine resistant breast cancer and lung cancer.
ORCID Identifier: 0000-0002-0677-8150
Key Words:
Drug Design
Cancer
Therapeutic Agents
Structural Activity Relationship
Breast Cancer
Phytoalexins
SELECTED PUBLICATIONS
Walker,Rashida R; Patel, Jankiben, R.; Gupta, Akash; Davidson, Michael A.; Williams,Christopher, C.; Payton-Stewart, Florastina; Boue, Stephen, M.; Burow,Matthew, E.; Khupse, Rahul; and Tilghman, Syreeta, L. International Journal of Molecular Sciences2022, 23(5):2887. DOI: 10.3390/ijms23052887
Wilson-Kennedy,Z.; Winfield, L.; Nielson, J.; Arriaga, E.; Kimble-Hill, A.; Payton-Stewart,F. Introducing the Journal of Chemical Education’s Special Issue onDiversity, Equity, Inclusion, and Respect in Chemistry Education Research andPractice. Journal of Chemical Education 2021. DOI: 10.1021/acs.jchemed.1c01219.
Payton-Stewart, Florastina LaTaya,Leyte L. Winfield, and Zakiya Wilson-Kennedy. Toward IntentionalDiversity, Equity, and Respect in Chemistry Research and Practice. Journalof Chemical Education 97 (8). ACS Division of Chemical Education and theAmerican Chemical Society Publications division.: 2041–44, 2020. https://pubs.acs.org/doi/10.1021/acs.jchemed.0c00963
Israel, Bridg’ette B.,Tilghman, Syreeta L., Parker-Lemieux, KiTani, and Payton-Stewart, Florastina. Phytochemicals: Current Strategies forTreating Breast Cancer. OncologyLetters 15: 7471-7478, 2018. DOI: 10.3892/ol.2018.8304
Gong, Jingjing, Munoz,Amanda, Pingali, Subramanya, Payton-Stewart, Florastina, Chan, Daniel,Freeman, James, Ghosh, Rita, Kumar, Addanki Pratap. Downregulation of STAT3/NF-κB potentiatesgemcitabine activity in pancreatic cancer cells. Molecular Carcinogenesis, 56 (2), 402-411,2017. DOI: 10.1002/mc.22503
Carriere,Patrick, Llopis, D. Shawn, Naiki, Annai, Nguyen, Gina, Phan, Tina, Nguyen, M.Mary, Preyan, C. Lynez, Yearby, Letecia, Pratt, Jamal, Davenport, Ian, Nguyen,A. Thu, Parker-Lemieux, KiTani, Payton-Stewart, Florastina,Williams, C. Christopher, Boue, M. Stephen, Tilghman, L. Syreeta. Glyceollin I Reverses Epithelial toMesenchymal Transition in Letrozole Resistance Through ZEB1. International Journal of EnvironmentalResearch and Public Health 13 (1), 10, 2016. DOI: 10.3390/ijerph13010010
Toro,Tasha B., Subramanya Pingali, Thao P. Nguyen, De S. Garrett, Kyr A. Dodson, KyA. Nichols, R A. Haynes, Florastina Payton-Stewart, and Terry J. Watt. KDAC8with High Basal Velocity Is Not Activated by N-Acetylthioureas. PloS One 11(1), 2016. https://pubmed.ncbi.nlm.nih.gov/26745872/
Pingali,S. and Donahue, J.P. and Payton-Stewart, F. Tetrahydroberberine, a pharmacologicallyactive naturally occurring alkaloid. Acta Crystallographica Section C71, 262-265, 2015. DOI: 10.1107/S2053229615004076
Payton-Stewart F,Tilghman SL, Williams LG & Winfield LL. Benzimidazoles diminish ERE
transcriptional activityand cell growth in breast cancer cells. Biochemical andBiophysical
Research Communications,PMID: 24997336, 450, (4), 1358-1362, 2014. DOI:
10.1016/j.bbrc.2014.06.130
Pingali, S. and Donahue, J.P. and Payton-Stewart, F. Weak C-H->X (X = O, N) Hydrogen Bondsin the Crystal Structure of Dihydroberberine. Acta Crystallographica Section C70,388-391, 2014. DOI: 10.1107/S2053229614003751
Payton-Stewart, F.,Pingali, S. and Donahue, J.P. Thechalcone derivative(E)-1-(4-fluorophenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-onemonohydrate. Acta Crystallographica69E: 558-559, 2013. https://doi.org/10.1107/S160053681300696X
Winfield,L.; Payton-Stewart, F. Celecoxiband Bcl-2: Emerging Possibilities for Anticancer Drug Design. FutureMedicinal Chemistry, 4 (3) 361-383, 2012. DOI: 10.4155/fmc.11.177
Payton-Stewart, Florastina,Bose, Rumu, Alworth, William, L., Kumar, Addanki, Ghosh, Rita. 4-methylcatechol-Induced Oxidative Stressin Metastatic Melanoma Cells Leads to Intrinsic Apoptotic Pathway. Biochemical Pharmacology 81 (10):1211-1218, 2011. doi: 10.1016/j.bcp.2011.03.005
Payton-Stewart*, Florastina,Jiang*, Quan, Elliott, Steven, Driver, Jennifer, Zhang, Qiang,Zheng, Shilong, Bhatnagar, Deepak , Boue, M. Stephen, Wiese, E. Thomas, Burow, E. Matthew, Wang ,Guangdi. Effects of 7-OSubstitutions on Estrogenic and Anti-Estrogenic Activities of DaidzeinAnalogues in MCF-7 Breast Cancer Cells. J.Med. Chemistry 53 (16): 6153-6163, 2010. DOI: 10.1016/j.bcp.2011.03.005
Payton-Stewart, Florastina,Boue, M. Stephen, Elliott, Steven, Zimmerman, Carla M., Skripnikova, Elena V., Ashe, Hasina,Tilghman, Syreeta L., Beckman, Barbara S., McLachlan, John A., Bhatnagar,Deepak, Wiese, Thomas E., Erhardt, Paul, Burow, Matthew E. Glyceollin I enantiomers distinctlyregulate ER-mediated gene expression. Steroids75 (12): 870-878, 2010. DOI: 10.1016/j.steroids.2010.05.007
Zimmermann, C., Tilghman, S., Boue, S., Salvo, V.A.,Elloitt, S., Williams, K., Skripnikova, E.V., Ashe, H., Payton-Stewart, F.,Vanhoy-Rhodes, L., Fonseca, J.P., Corbitt, C., Collins-Burow, B., Howell, M.,Lacey, M., Shih, B., Carter-Wientjes, C., Cleveland, T., McLachlan, J., Wiese,T., Beckman, B., Burow, M.E. GlyceollinI, a novel anti-estrogen phytoalexin isolated from activated soy. J Pharmacol Experimental Therapeutics 332(1): 35-45, 2010. doi: 10.1124/jpet.109.160382
Payton-Stewart, F.,Schoene, N., Kim, Y., Burow, M.E., Cleveland, T., Boue, S., and Wang, T. Molecular effects of soy phytoalexinsglyceollin in human prostate cancer cells, LNCaP. Molecular Carcinogenesis 48 (9): 862-71,2009.doi: 10.1002/mc.20532
Boue, S., Tilghman, S.,Elloitt, S., Zimmerman, C., Williams, KY, Payton-Stewart, F., Miraflor,A., Howell, M., Shih, BY, Carter-Wientjes, CH, Segar, C., Beckman, BS., Wiese,TE., Cleveland, T., McLachlan, J., and Burow, ME. Identification of the potent phytoestrogenglycinol in elicited soybean (Glycine max). Endocrinology 150 (5): 2446-53, 2008. doi: 10.1210/en.2008-1235
Payton, Florastina,Sandusky, Peter, and Alworth, William. Curcumin:An NMR Study. Journal of NaturalProducts 70 (2), 143-146, 2007. https://pubs.acs.org/doi/10.1021/np060263s
Mague, J.T., Alworth, W.L., Payton, F.L. Curcumin and derivatives. Acta Crystallographica 60C:608-610. 2004.
