Cell and molecular aspects of nuclear receptor regulation by environmental and developmental therapeutic ligands.
The primary theme of research in the Wiese lab is study of the molecular mechanisms involved in nuclear receptor mediated endocrine disruption and pharmacotherapy. Projects underway include characterizations of gene, receptor and tissue specific effects of hormone active environmental chemicals, natural products, pharmaceuticals, personal care products and dietary supplements as well as developmental therapeutics. The goal of these studies is to define the endocrine disruption of these substances as primary molecular level events that can contribute to hormone mediated mechanisms of cancer promotion and progression. These projects involve cellular, molecular, and biochemical techniques as well as molecular modeling approaches to characterizing estrogen, androgen and progestin activity. Dr. Wiese has published research involving endocrine disruption, structure-activity relationships of hormone active chemicals and estrogen receptor mediated effects on gene induction and proliferation in breast cancer cell models.
BS Biology(Chemistry minor) 1984, University of Michigan – Flint
PhD Biochemistry 1995, Wayne State University School of Medicine
Postdoctoral Fellowship Molecular Toxicology 1995-98, University of North Carolina at Chapel Hill School of Medicine
https://www.ncbi.nlm.nih.gov/myncbi/thomas.wiese.1/bibliography/public/
Yanagihara R, Berry MJ, Carson MJ, Chang SP, Corliss H, CoxMB, Haddad G, Hohmann C, Kelley ST, Lee ESY, Link BG, Noel RJ, Jr., Pickrel J,Porter JT, Quirk GJ, Samuel T, Stiles JK, Sy AU, Taira DA, Trepka MJ, VillaltaF, Wiese TE (2021) Building a DiverseWorkforce and Thinkforce to Reduce Health Disparities. International Journal of Environmental Research and Public Health Vol.18, No. 4, pp. 1569
Guo S, Zhang C, Bratton M, Mottamal M, Liu J, Ma P, Zheng S,Zhong Q, Yang L, Wiese T, Wu Y, Ellis M, Matossian M, Burow M, Miele L, HoutmanR, Wang G (2018) ZB716, a SteroidalSelective Estrogen Receptor Degrader (SERD), is Orally Efficacious in Blocking TumorGrowth in Mouse Xenograft Models. OncotargetVol. 9, pp. 6924-6937
Liu J, Zheng S, Guo S, Zhang C, Zhong Q, Zhang Q, Ma P,Skripnikova EV, Bratton MR, Wiese TE, Wang G (2017) Rational Design of a Boron-Modified Triphenylethylene (GLL398) as anOral Selective Estrogen Receptor Downregulator. ACS Medicinal Chemistry Letters Vol. 8, No. 1, pp. 102-106
Wells K, Lima D, Meade C, Muñoz-Antonia T, Scarinci I,McGuire A, Gwede C, Pledger W, Partridge E, Lipscomb J, Matthews R, Matta J,Flores I, Weiner R, Turner T, Miele L, Wiese T, Fouad M, Moreno C, Lacey M,Christie D, Price-Haywood E, Quinn G, Coppola D, Sodeke S, Green B, LichtveldM, investigators obotRGB (2013) AssessingNeeds and Assets for Building a Regional Network Infrastructure to ReduceCancer Related Health Disparities. EvalProgram Plann Vol. 44C, pp. 14-25
Schenck K, Rosenblum L, Wiese TE, Wymer L, Dugan N, WilliamsD, Mash H, Merriman B, Speth T (2012) Removalof estrogens and estrogenicity through drinking water treatment. Journal of Water and Health Vol. 10, No.1,
Khupse RS, Sarver JG, Trendel JA, Bearss NR, Reese MD, WieseTE, Boue SM, Burow ME, Cleveland TE, Bhatnagar D, Erhardt PW (2011) Biomimetic Syntheses and AntiproliferativeActivities of Racemic, Natural (-), and Unnnatural (+) Glyceollin I. Journal of Medicinal Chemistry Vol. 54,No. 10, pp. 3506-3523
Boue SM, Burow ME, Wiese TE, Shih BY, Elliott S,Carter-Wientjes CH, McLachlan JA, Bhatnagar D (2011) Estrogenic and Antiestrogenic Activities of Phytoalexins from RedKidney Bean (Phaseolus vulgaris L.). Journalof Agricultural & Food Chemistry Vol. 59, No. 1, pp. 112-120
Srisawat P, Streiffer AB, Barbeau DN, Wiese TE, Grimm D,Skaggs BK, Andrew J. Englande J, Reimers RS (2010) Reduction of estrogenic activity in wastewater following treatment withferrate. Proceedings of the WaterEnvironment Federation Vol. 2010,
Boue SM, Wiese TE, Nehls S, Burow ME, Elliott S,Carter-Wientjes CH, Shih BY, McLachlan JA, Cleveland TE (2003) Evaluation of the estrogenic effects oflegume extracts containing phytoestrogens. Journal of Agricultural & Food Chemistry Vol. 51, No. 8, pp. 2193-9
Coleman KP, Toscano WA, Wiese TE (2003) QSAR Models of the in vitro Estrogen Activity of Bisphenol A Analogs. Quantitative Structure-Activity Relationships Vol. 22, pp. 78-88
Key words/Tags: endocrine disruption, nuclear receptors, estrogen, androgen
Website: https://www.xula.edu/directory//people/thomas-e.-wiese,-phd.html
