Dr. Anil Mishra, PhD., is Professor of Medicine and Endowed Chair, Edward G. Schlieder Educational Foundation and the Director of Tulane Eosinophilic Disorder Center at the Section of Pulmonary Diseases, Tulane School of Medicine, New Orleans, LA. Earlier, Dr. Mishra served as a faculty member at Allergy and Immunology Division, Cincinnati Children's Hospital Medical Center, Cincinnati, OH and Professor Medicine, Case Western Reserve University Medical College, Cleveland, OH before joining the Tulane University School of Medicine, New Orleans, LA.
Dr. Mishra's most important contribution was to establish that eosinophils are the resident cell that home prenatally in the gastrointestinal tract (Mishra et al. J. Clin. Invest. 1999, 103, 1719-27) and the gastrointestinal tract (esophagus to colon) constitutively expresses eotaxin-1(an eosinophil selective chemoattractant). Dr. Mishra developed a first murine model of asthma associated eosinophilic esophagitis (Mishra et al. J. Clin. Invest. 2001, 107, 83-90). His findings implicated aeroallergen in the etiology of EoE and suggested that esophageal eosinophilic inflammation is mechanistically associated with pulmonary inflammation (Mishra et al. J. Immunology 2002, 168, 2464-69 and Gastroenterology, 2003, 125. 1419-27).His research implicated iNKT cells to the food and indoor insect allergens induce EoE and iNKT cell neutralization as a possible future therapy of EoE (Clinical and Translational Immunology, 2013). He patents IL-15 responsive T cell associated molecules as a non-invasive biographers for EoE that differentiate EoE from GERD. Current interest is on the role of IL-15 and IL-18 in pulmonary , pancreatitic and gastrointestinal eosinophilic inflammation. Most recently Dr. Mishra's laboratory showed the significance of IL-15 in recovering allergen-induced airway obstruction (J. Allergy Clin Immunology 2017) and reported a critical role of eosinophils biology.. Dr. Mishra showed that apart from IL-5, Il-18 also differentiate eosinophils and transform IL-5 generated naïve eosinophils to CD101+CD274+ pathogenic eosinophils (J. Allergy Clin Immunology 2018). Earlier, he also reported that CD274 expressed eosinophils are possible non-invasive biomarkers of EoE (Case Report in Gastroenterology, 2017). Dr. Mishra’s current research is focused on the role neuropeptide (VIP) in esophageal motility in EoE and GERD. VIP role in eosinophils and mast cell trafficking in EoE is shown via binding to its receptor CRTH2 present on both eosinophils and mast cells (Cell Mol Gastro Hepatol (JCMGH) 2017). In addition, Dr. Mishra showed the preventive role of rIL-15 in pulmonary and pancreatic fibrosis (AJP-Gastroenterology 2019 and Am. J Res. Mol. Cell Biol. 2019). Furthermore, Dr. Mishra’s laboratory developed first chemical-induced mouse model of pancreatic cancer that also metastasize into lung. The model is now leaded to testing several drugs to treat pancreatic and lung cancer.
Dr. Mishra is an elected fellow of the American Academy of Allergy Asthma Immunology (FAAAAI), and American Gastrointestinal Association (FAGA). He has over 100 peer-reviewed articles, book chapters and reviews on molecular mechanisms of the pulmonary and gastrointestinal toxicity and allergic responses in high impact factor journals. His publications are cited by ~ 7500. Some of his publications are cited more than 6 to 700 till 2018. Dr. Mishra's research has been supported by the 2-different institutes of National Institutes of Health (NIDDK and NIAID) He is serving in a number of study sections as member in NIH.
ORCID identifier: 0000-0003-4266-4684
MyNCBI Link: https://www.ncbi.nlm.nih.gov/myncbi/anil.mishra.1/bibliography/public/
Selected Publications:
· ManoharM, Verma AK, Ventateshaiah SU, MishraA.Significance of eosinophils in pathogenesis of pancreatitis associatedmalignancy. Journalof Gastroenterology, Pancreatology & Liver Disorders, 2017;4(7): 1-9. PMID: 29756031
· 13.Kandikattu HM, Manohar M, Venkateshaiah SU, Yadavalli C, Mishra A. Chronic inflammationpromotes epithelial-mesenchymal transition-mediated malignant phenotypes andlung injury in experimentally-induced pancreatitis . Life Science. PMID: 3404881
· 14.Hemanth Kumar Kandikattu, Murli Manohar, Sathisha Upparahalli Venkateshaiah, ChandrasekharYadavalli,AnilMishra. Chronicinflammation promotes epithelial-mesenchymal transition-
· mediatedmalignant phenotypes and lung injury in experimentally-induced pancreatitis. Life Sciences,278, 2021,
· 119640.PMID:34048812
15. HemanthKumar Kandikattu, M Manohar, Sandeep Kumar, Verma AK, Chandrasekhar
· Yadavalli,SathishaUpparahalli Venkateshaiah, AnilMishra. Macrophages-inducedIL-18–mediated eosinophilic inflammation promotes characteristics of pancreaticmalignancy. LifeSci Alliance. 2021Jun 28;4(8):e202000979. PMID:34183442
Topics/Keywords: Eosinophils, NLRP3, IL-18 pancreatitis, Malignancy
Lab website: · https://medicine.tulane.edu/departments/medicine-pulmonary-diseases/research/eosinophilic
